Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

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Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents.

Sublethal ischemia protects tissues against subsequent, more severe ischemia through the upregulation of endogenous mechanisms in the affected tissue. Sublethal ischemia has also been shown to upregulate protective mechanisms in remote tissues. A brief period of ischemia (5-10 min) in the hind limb of mammals induces self-protective responses in the brain, lung, heart and retina. The effect is ...

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Remote Ischemic Preconditioning and Diabetic Macular Edema

Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influence of RIPC on diabetic macular edema (DME) as a chronic ischemic condition in patients who were ...

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Effects of remote limb ischemic preconditioning on pulmonary function tests and maximal oxygen uptake

Introduction: Ischemic preconditioning (IPC) protects skeletal muscles from ischemia-reperfusion injury and improves physical exercise performance. The purpose of the present study was to determine whether application of remote ischemic preconditioning (RIPC) of upper limbs would affect the pulmonary function tests and the maximal oxygen consumption (VO2max). Methods: Twenty healthy trained...

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Transient limb ischemia induces remote ischemic preconditioning in vivo.

BACKGROUND Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from those undergoing preconditioning. We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size. METHODS AN...

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Bilateral Upper Limb Remote Ischemic Preconditioning Improves Anaerobic Power

Purpose: Ischemic preconditioning (IPC) has been used to protect myocardial cells against ischemiareperfusion injury and is recently utilized for improving exercise performance. It is unknown whether remote IPC (RIPC) to tissues not involved in exercise can induce similar exercise improvements and what “dose” of IPC is necessary to induce exercise performance benefits. This study determined if ...

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ژورنال

عنوان ژورنال: Journal of Visualized Experiments

سال: 2015

ISSN: 1940-087X

DOI: 10.3791/52213